Package: gsDesignNB
Version: 0.3.2
Title: Sample Size and Simulation for Negative Binomial Outcomes
Authors@R: c(
    person("Keaven", "Anderson", email = "keaven_anderson@merck.com", role = c("aut", "cre")),
    person("Hongtao", "Zhang", role = "aut"),
    person("Andrea", "Maes", role = "aut"),
    person("Nan", "Xiao", role = "ctb"),
    person("Merck & Co., Inc., Rahway, NJ, USA and its affiliates", role = "cph",
           comment = c(ROR = "02891sr49"))
    )
Description: Provides tools for planning and simulating recurrent event
        trials with overdispersed count endpoints analyzed using
        negative binomial (or Poisson) rate models. Implements sample
        size and power calculations for fixed designs with variable
        accrual, dropout, maximum follow-up, and event gaps, including
        methods of Zhu and Lakkis (2014) <doi:10.1002/sim.5947> and
        Friede and Schmidli (2010) <doi:10.3414/ME09-02-0060> as well
        as extensions for score-test sizing and gaps between events.
        Supports group sequential monitoring by building on the
        'gsDesign' package. Includes recurrent-event simulation
        utilities (including seasonal rates), interim data truncation,
        Wald and score-test inference for rate ratios, and information
        estimation and sample size re-estimation with or without
        treatment-group labels.
License: GPL (>= 3)
URL: https://keaven.github.io/gsDesignNB/,
        https://github.com/keaven/gsDesignNB
BugReports: https://github.com/keaven/gsDesignNB/issues
Encoding: UTF-8
Depends: R (>= 4.1.0)
Imports: data.table, gsDesign (>= 3.10.0), simtrial, stats, MASS
Suggests: glmmTMB, httpuv, testthat (>= 3.0.0), knitr, rmarkdown,
        ggplot2, dplyr, lt (>= 0.5), scales, shiny, foreach, doFuture,
        future, future.apply, gridExtra
VignetteBuilder: knitr
Config/testthat/edition: 3
Roxygen: list(markdown = TRUE)
Config/roxygen2/version: 8.0.0
Config/pak/sysreqs: libicu-dev
Repository: https://keaven.r-universe.dev
Date/Publication: 2026-10-17 04:06:11 UTC
RemoteUrl: https://github.com/keaven/gsdesignnb
RemoteRef: HEAD
RemoteSha: 8fe886a4173131518a5355b9509d74ea97fe46ad
NeedsCompilation: no
Packaged: 2026-10-17 04:50:07 UTC; root
Author: Keaven Anderson [aut, cre],
  Hongtao Zhang [aut],
  Andrea Maes [aut],
  Nan Xiao [ctb],
  Merck & Co., Inc., Rahway, NJ, USA and its affiliates [cph] (ROR:
    <https://ror.org/02891sr49>)
Maintainer: Keaven Anderson <keaven_anderson@merck.com>